Association between periodontitis and fibrotic progression of non?alcoholic fatty liver among Japanese adults

Aim Non-alcoholic fatty liver (NAFL) is known to develop into fibrosis, which increases the risk of cirrhosis and cancer. The association between periodontal condition fibrotic progression NAFL unclear. This study aimed clarify this longitudinal association. Materials Methods Among 4812 participants aged 35–64 years undergoing annual health check-ups 2003 2004, follow-up 5 later, 392 were diagnosed with NAFL. After excluding fibrosis at baseline, 341 followed up for years. disease score ??1.455 was used evaluate probability presence fibrosis. Results During period, 10.6% progressed A higher clinical attachment level (CAL) tended be associated incidence in logistic regression analysis (odds ratio [OR] 1.82, 95% confidence interval [CI], 0.94–3.49, p = .074). stratified by obesity revealed a significant CAL obese (OR 2.87, CI, 1.23–6.69, .015), but not non-obese participants. Conclusion Higher an increased adults